A prevalência dos distúrbios neurológicos da Síndrome Pós-Covid
uma revisão sistemática
DOI:
https://doi.org/10.47385/cmedunifoa.2075.2025%25gPalavras-chave:
Efeitos COVID-19, Sintomas COVID-19, COVID-19, pandemia COVID-19, COVID longaResumo
Esta revisão sistemática analisou 21 artigos da base de dados Pubmed publicados entre os anos de 2023 e 2025. O objetivo foi identificar o nível de prevalência das sequelas neurológicas da Síndrome Pós-Covid. Concluímos que as sequelas de maior prevalência foram a fadiga, comprometimento cognitivo, ansiedade e depressão. As de média prevalência foram alterações sensoriais (olfato e paladar) e motoras (problemas de memória, déficits de atenção e sequelas motoras).
Referências
ANUAR, M. A. et al. Severe and rare neurological manifestations following COVID-19 infection in children: A Malaysian tertiary centre experience. Brain & Development, v. 45, n. 10, p. 547–553, nov. 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37661525/. Acesso em: 15 mar. 2025.
BIRBERG THORNBERG, U. et al. Neurocognitive deficits in COVID-19 patients five months after discharge from hospital. Neuropsychological Rehabilitation, v. 33, n. 10, p. 1599–1623, dez. 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36239662/. Acesso em: 15 mar. 2025.
BORGES, et al. Neurological and neuropsychiatric manifestations of post-COVID-19 condition in South America: a systematic literature review. Feb, v. 82, n. 1, p. 1–8, fev. 2024.
CHAROENPORN, V. et al. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial. Psychiatry and Clinical Neurosciences, v. 78, n. 10, p. 595–604, out. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/39072958/. Acesso em: 15 mar. 2025.
CHOW, S. K. et al. A study of neuropsychiatric manifestations in COVID-19 infection in inpatients and its long-term outcomes in Malaysia. The Medical Journal of Malaysia, v. 78, n. 7, p. 907–913, dez. 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38159927/. Acesso em: 15 mar. 2025.
DIAZ, et al. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infectious Diseases, v. 22, n. 4, p. e102–e107, dez. 2021.
FARAHANI, R. H.; AJAM, A.; NAEINI, A. R. Effect of fluvoxamine on preventing neuropsychiatric symptoms of post COVID syndrome in mild to moderate patients, a randomized placebo-controlled double-blind clinical trial. BMC infectious diseases, v. 23, n. 1, p. 197, 31 mar. 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37003990/. Acesso em: 15 mar. 2025.
FIRESTEIN, M. R. et al. Assessment of Neurodevelopment in Infants With and Without Exposure to Asymptomatic or Mild Maternal SARS-CoV-2 Infection During Pregnancy. JAMA network open, v. 6, n. 4, p. e237396, 3 abr. 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37036706/. Acesso em: 15 mar. 2025.
GARCÍA-VICENTE, P. et al. Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy. PloS One, v. 18, n. 3, p. e0283758, 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36996121/. Acesso em: 15 mar. 2025.
GOLDSTEIN, D. S. et al. Persistent Autonomic and Immunologic Abnormalities in Neurologic Post-Acute Sequelae of SARS-CoV2 Infection. Neurology, v. 103, n. 6, p. e209742, 24 set. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/39173103/. Acesso em: 15 mar. 2025.
GOYAL, M. et al. Long-Term Growth and Neurodevelopmental Outcomes of Neonates Infected with SARS-CoV-2 during the COVID-19 Pandemic at 18-24 Months Corrected Age: A Prospective Observational Study. Neonatology, v. 121, n. 4, p. 450–459, 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38583433/. Acesso em: 15 mar. 2025.
KLÍROVÁ, M. et al. Transcranial direct current stimulation (tDCS) in the treatment of neuropsychiatric symptoms of long COVID. Scientific Reports, v. 14, n. 1, p. 2193, 25 jan. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38272997/. Acesso em: 15 mar. 2025.
MECA-GARCÍA, J. M. et al. Neuropsychiatric symptoms of patients two years after experiencing severe COVID-19: A mixed observational study. Medicina Clinica, v. 163, n. 8, p. 383–390, 25 out. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38964970/. Acesso em: 15 mar. 2025.
MINA, Y. et al. Deep Phenotyping of Neurologic Postacute Sequelae of SARS-CoV-2 Infection. Neurology(R) Neuroimmunology & Neuroinflammation, v. 10, n. 4, p. e200097, jul. 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37147136/. Acesso em: 15 mar. 2025.
PATIL, T. et al. Evaluation of Neuropsychiatric outcomes in patients hospitalized with COVID-19 in a nationwide Veterans Health Administration cohort. Psychiatry Research, v. 336, p. 115913, jun. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38643518/. Acesso em: 15 mar. 2025.
SALZMANN, S. et al. Side-effect expectations are associated with disability, physical fitness, and somatic symptoms 3 months after post-COVID neurological inpatient rehabilitation. Journal of Psychosomatic Research, v. 186, p. 111902, nov. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/39197231/. Acesso em: 15 mar. 2025.
SITE CORONAVÍRUS BRASIL. Disponível em: https://covid.saude.gov.br/. Acesso em: [Inserir a data de acesso].
TALHARI C. et al. Prevalence of and risk factors for post-COVID: results from a survey of 6,958 patients from Brazil. An Acad Bras Cienc. 2023;95(1):e20220143.
TANASHYAN, M. et al. A prospective randomized, double-blind placebo-controlled study to evaluate the effectiveness of neuroprotective therapy using functional brain MRI in patients with post-covid chronic fatigue syndrome. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, v. 168, p. 115723, dez. 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37862966/. Acesso em: 15 mar. 2025.
WEE, L. E. et al. Long-term neuropsychiatric sequelae of Delta versus Omicron SARS-CoV-2 infection. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 1 v. 30, n. 4, p. 531–539, abr. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38141822/. Acesso em: 15 mar. 2025.
WRIGHT, T. J. et al. Low growth hormone secretion associated with post-acute sequelae SARS-CoV-2 infection (PASC) neurologic symptoms: A case-control pilot study. Molecular and Cellular Endocrinology, v. 579, p. 112071, 1 jan. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37816478/. Acesso em: 15 mar. 2025.
YANGIN ERGON, E. et al. The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study. Italian Journal of Pediatrics, v. 50, n. 1, p. 34, 27 fev. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38413995/. Acesso em: 15 mar. 2025.
YEA, C. et al. Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques, v. 51, n. 1, p. 40–49, jan. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36597285/. Acesso em: 15 mar. 2025.
ZHAO, C. et al. Brain magnetic resonance imaging findings in children with neurological complications of coronavirus disease 2019 (Omicron variant): a multicenter retrospective observational study. Pediatric Radiology, v. 54, n. 6, p. 1012–1021, maio 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38538753/. Acesso em: 15 mar. 2025.
ZHAO, D. et al. Optic Neuritis and Cranial Neuropathies Diagnosis Rates before Coronavirus Disease 2019, in the Initial Pandemic Phase, and Post-Vaccine Introduction. Ophthalmology, v. 131, n. 1, p. 78–86, jan. 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37634758/. Acesso em: 15 mar. 2025.
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